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Vanillotoxin 3（VaTx3）
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：10VAN003- 廠商性質(zhì)：代理商
- 更新時(shí)間：2024-10-30
- 訪 問(wèn) 量：1782
產(chǎn)品介紹
Vanillotoxin 3(VaTx3)
選擇性激活哺乳動(dòng)物辣椒素受體（TRPV1）
Vanillotoxin 3: Toxin description
Vanillotoxin-3 (VaTx3) has been isolated from the venom of Psalmopoeus cambridgei, a West Indies tarantula. It is a 34 amino acids peptide with three disulfide bridges with an ICK motif. It selectively activates mammalian TRPV1 (capsaicin receptor), a non-selective cation channel expressed by sensory neurons of the pain pathway with an EC50 value of 0.45 ± 0.04 µM. It is more potent than VaTx1 (20-fold) and VaTx2 (2-fold), two other analogues of VaTx3 with closely related sequences and isolated from the same venom. VaTx3 probably interacts with distinct regions of the channel than capsaicin. VaTx3 does not affect TRPV2, TRPV3, TRPV4, TRPA1, TRPM8, Kv1.2 (KCNA2), Kv2.1 (KCNB1) or Kv4.2 (KCND2). In mice, VaTx3 elicits pain-related behaviors, such as licking and flinching of the affected limb. Edema is evidenced in the paw of toxin-injected mice.
氨基酸序列：
Glu-Cys2-Arg-Trp-Tyr-Leu-Gly-Gly-Cys9-Lys-Glu-Asp-Ser-Glu-Cys15-Cys16-Glu-His-Leu-Gln-Cys21-His-Ser-Tyr-Trp-Glu-Trp-Cys28-Leu-Trp-Asp-Gly-Ser-Phe-NH2
二硫鍵：Disulfide bonds between Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28
長(zhǎng)度 (aa)：34
分子式： C184H241N47O55S6
分子量：4179.6 Da
外觀： White lyophilized solid
可溶性： may be difficult to solubilize
CAS 號(hào)： not available
來(lái)源：Synthetic
純度： > 98%
產(chǎn)品信息
10VAN003-00100 | VaTx3 | 0.1mg |
